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\u672c\u6b21\u5e38\u898f\u6279\u51c6\u4e3b\u8981\u57fa\u65bc\u4e00\u9805\u591a\u4e2d\u5fc3\u3001\u96a8\u6a5f\u3001\u958b\u653e\u3001\u967d\u6027\u85e5\u5c0d\u7167\u7684\u2162\u671f\u81e8\u5e8a\u7814\u7a76\uff08RC48-C016\u7814\u7a76\uff0cNCT05302284\uff09\uff0c\u65e8\u5728\u8a55\u4f30\u7279\u745e\u666e\u5229\u55ae\u6297\u806f\u5408\u7dad\u8fea\u897f\u59a5\u55ae\u6297\u5c0d\u6bd4\u5409\u897f\u4ed6\u6ff1\u806f\u5408\u9806\u9251\/\u5361\u9251\u5728\u65e2\u5f80\u672a\u63a5\u53d7\u7cfb\u7d71\u6297\u816b\u7624\u6cbb\u7642\u7684HER2\u8868\u9054\uff08\u5b9a\u7fa9\u70baHER2 IHC 1+\u30012+\u62163+\uff09\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027UC\u60a3\u8005\u4e2d\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\uff0c\u7531\u5317\u4eac\u5927\u5b78\u816b\u7624\u91ab\u9662\u90ed\u8ecd\u6559\u6388\u548c\u4e2d\u570b\u91ab\u5b78\u79d1\u5b78\u9662\u816b\u7624\u91ab\u9662\u5468\u611b\u840d\u6559\u6388\u64d4\u4efb\u4e3b\u8981\u7814\u7a76\u8005\uff0c\u5728\u5168\u570b74\u5bb6\u81e8\u5e8a\u4e2d\u5fc3\u958b\u5c55\u3002\u8a72\u7814\u7a76\u540c\u6642\u652f\u6301\u4e86\u4eca\u5e745\u6708\u6279\u51c6\u7684\u7279\u745e\u666e\u5229\u55ae\u6297\u4e00\u7dda\u6cbb\u7642HER2\u8868\u9054\u5c3f\u8def\u4e0a\u76ae\u764c\u65b0\u9069\u61c9\u75c7\u7684\u7372\u6279\u4e0a\u5e02\u3002<\/p>\n\n\n\n

RC48-C016\u7814\u7a76\u7d50\u679c\u986f\u793a1<\/sup>\uff0c\u4e3b\u8981\u7814\u7a76\u7d42\u9ede\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff0c\u57fa\u65bc\u7368\u7acb\u5f71\u50cf\u8a55\u4f30\uff09\u548c\u7e3d\u751f\u5b58\u671f\uff08OS\uff09\u9054\u5230\u201c\u96d9\u7d42\u9ede\u967d\u6027\u7d50\u679c\u201d\u3002\u8207\u50b3\u7d71\u5316\u7642\u76f8\u6bd4\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u806f\u5408\u7dad\u8fea\u897f\u59a5\u55ae\u6297\u4e00\u7dda\u6cbb\u7642HER2\u8868\u9054\u665a\u671fUC\u7684\u4e2d\u4f4dPFS\u5be6\u73fe\u7ffb\u756a\uff0813.1\u500b\u6708 vs. 6.5\u500b\u6708\uff0c\u98a8\u96aa\u6bd4HR=0.36\uff0c95%CI\uff1a0.28-0.46\uff1bp<<0.0001\uff09\uff0c\u4e2d\u4f4dOS\u7372\u5f97\u986f\u8457\u5ef6\u9577\uff0831.5\u500b\u6708 vs. 16.9\u500b\u6708\uff0cHR=0.54\uff0c95%CI\uff1a0.41-0.73\uff1bp<<0.0001\uff09\uff0c\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\u5927\u5e45\u63d0\u5347\uff0876.1% vs. 50.2%\uff09\uff0c\u4e2d\u4f4d\u7642\u6548\u6301\u7e8c\u6642\u9593\u5ef6\u9577\u6578\u500d\uff0814.6\u500b\u6708 vs. 5.6\u500b\u6708\uff09\u3002<\/p>\n\n\n\n

\u806f\u5408\u6cbb\u7642\u7d44\u5c0d\u6bd4\u50b3\u7d71\u5316\u7642\u5927\u5e45\u6539\u5584\u5b89\u5168\u6027\u3002\u622a\u81f3\u76ee\u524d\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u5df2\u5be6\u73fe\u5c0d\u665a\u671f\u5c3f\u8def\u4e0a\u76ae\u764c\u4e00\u7dda\u53ca\u5f8c\u7dda\u6cbb\u7642\u7684\u8986\u84cb\u3002\u6b64\u6b21\u4e8c\u7dda\u53ca\u4ee5\u4e0a\u9069\u61c9\u75c7\u7372\u5f97\u5e38\u898f\u6279\u51c6\uff0c\u9032\u4e00\u6b65\u592f\u5be6\u4e86\u7279\u745e\u666e\u5229\u55ae\u6297\u5728\u665a\u671f\u5c3f\u8def\u4e0a\u76ae\u764c\u6cbb\u7642\u9818\u57df\u7684\u5faa\u8b49\u91ab\u5b78\u8b49\u64da\uff0c\u4e5f\u5b8c\u5584\u4e86\u5176\u8986\u84cb\u4e0d\u540c\u6cbb\u7642\u968e\u6bb5\u7684\u81e8\u5e8a\u61c9\u7528\u4f48\u5c40\uff0c\u70ba\u4e2d\u570b\u665a\u671f\u5c3f\u8def\u4e0a\u76ae\u764c\u60a3\u8005\u5e36\u4f86\u66f4\u591a\u6cbb\u7642\u9078\u64c7\u548c\u9577\u671f\u7372\u76ca\u7684\u53ef\u80fd\u3002<\/p>\n\n\n\n

<\/p>\n\n\n\n

\u3010\u53c3\u8003\u6587\u737b\u3011<\/h5>\n\n\n\n
\n
1.Sheng X,et al.; RC48-C016 Trial Investigators. Disitamab Vedotin plus Toripalimab in HER2-Expressing Advanced Urothelial Cancer. N Engl J Med. 2025 Dec 11;393(23):2324-2337.<\/h5>\n<\/div><\/div>\n\n\n\n
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1. \u672c\u6750\u6599\u65e8\u5728\u50b3\u905e\u524d\u6cbf\u8cc7\u8a0a\uff0c\u7121\u610f\u5411\u60a8\u505a\u4efb\u4f55\u7522\u54c1\u7684\u63a8\u5ee3\uff0c\u4e0d\u4f5c\u70ba\u81e8\u5e8a\u7528\u85e5\u6307\u5c0e\u3002<\/em><\/h6>\n\n\n\n
2. \u82e5\u60a8\u60f3\u77ad\u89e3\u5177\u9ad4\u75be\u75c5\u8a3a\u7642\u8cc7\u8a0a\uff0c\u8acb\u9075\u5f9e\u91ab\u7642\u885b\u751f\u5c08\u696d\u4eba\u58eb\u7684\u610f\u898b\u8207\u6307\u5c0e\u3002<\/em><\/h6>\n<\/div>\n\n\n\n

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